# Discovery of Triazone Derivatives Containing Acylhydrazone and Phenoxypyridine Motifs as Novel Insecticidal and Antiphytopathogenic Fungus Agents

## TL;DR

Researchers discovered new triazone compounds that effectively kill aphids and fungi, with some showing better performance than existing pesticides.

## Contribution

The study introduces novel triazone derivatives with acylhydrazone and phenoxypyridine motifs as promising insecticidal and fungicidal agents.

## Key findings

- Compounds 3i and 3e showed insecticidal activity comparable to pymetrozine against bean aphids.
- Compounds 3c, 3e, and 3f exhibited larvicidal activity against C. pipiens pallens.
- Twelve compounds showed better fungicidal activity than carbendazim against cercospora arachidicola hori.

## Abstract

A series of novel triazone derivatives containing acylhydrazone and phenoxypyridine motifs were designed, synthesized, and evaluated for their biological activities. The bioassay results indicated that most of the target compounds exhibited excellent insecticidal activities against bean aphids. In particular, compounds 3i and 3e showed excellent aphicidal activities comparable to pymetrozine, thus emerging as novel insecticidal lead compounds. Additionally, compounds 3c (60%), 3e (60%), and 3f (60%) exhibited good larvicidal activities against C. pipiens pallens at 0.5 mg/kg. Further fungicidal activity tests revealed that most derivatives exhibited broad-spectrum fungicidal activities. A total of twelve compounds exhibited better fungicidal activities against cercospora arachidicola hori than carbendazim, and eight compounds exhibited better fungicidal activities against fusarium moniliforme than carbendazim. This work suggests that compound 3e could serve as an insecticidal lead compound for further structural optimization.