# The many facets of sustainability in medicinal chemistry: our personal experience

**Authors:** Bianca Martinengo, Eleonora Diamanti, Elisa Uliassi, Maria Laura Bolognesi

PMC · DOI: 10.1039/d5md00882d · RSC Medicinal Chemistry · 2025-12-30

## TL;DR

This paper discusses how sustainability should be central in drug development by combining green chemistry and one health principles.

## Contribution

The paper introduces a framework integrating Green Chemistry and One Health into medicinal chemistry practices.

## Key findings

- Sustainability must be embedded in all aspects of medicinal chemistry.
- Using renewable feedstocks can lead to ethically sound and environmentally responsible medicines.

## Abstract

Sustainability cannot be an afterthought; it must be embedded into every framework of medicinal chemistry. This opinion piece explores how integrating the dual pillars of Green Chemistry and One Health into drug design and development may drive innovation. Through case studies using renewable feedstocks, we highlight opportunities to create medicines that are effective, ethically sound, and environmentally responsible, for a more sustainable future.

Sustainability cannot be an afterthought; it must be embedded into every framework of medicinal chemistry.

## Full-text entities

- **Diseases:** cytotoxicity (MESH:D064420), African animal trypanosomiasis (MESH:D014353), parasitic disease (MESH:D010272), tuberculosis (MESH:D014376), VBPD (MESH:D000079426)
- **Chemicals:** carbon (MESH:D002244), petroleum ether (MESH:C004544), 2-methylcardol (-), hexanes (MESH:D006586), anacardic acid (MESH:C088115), ruthenium (MESH:D012428), cardol (MESH:C041328), cardanol (MESH:C038590), lipids (MESH:D008055), quinone (MESH:C004532)
- **Species:** Trypanosoma brucei brucei (subspecies) [taxon 5702], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12784498/full.md

## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC12784498/full.md

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Source: https://tomesphere.com/paper/PMC12784498