# Dexketoprofen Time‐Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross‐Over Controlled Trial

## TL;DR

This study tested if taking Dexketoprofen only during the day after wisdom tooth removal helps recovery more than taking it twice daily.

## Contribution

The study introduces a pilot trial on time-dependent administration of Dexketoprofen for postoperative recovery.

## Key findings

- Chronotherapy group showed faster pain recovery at 24, 48, and 72 hours.
- No significant differences in swelling or inflammatory markers between groups.
- Daytime-only administration had fewer overall complications.

## Abstract

To assess how chronotherapy influences recovery after bilateral third molar extraction when Dexketoprofen is administered as an anti‐inflammatory agent.

A randomized cross‐over controlled trial with 10 patients with bilateral impacted third molar extraction was enrolled. For 7 days after the surgery, the chronotherapy group was prescribed one dose of Dexketoprofen (25 mg) limited to daytime, while the control group were given two doses per day (every 12 h). Pain intensity was recorded at baseline, 24, 48, and 72 h, while facial swelling parameters were evaluated at baseline, 24, 72, and 168 h (Day 7) postoperatively. Also, the inflammatory profile was analyzed for each patient by blood samples at baseline, 72 and 168 h. The concentrations of IL‐1β, IL‐1a, IL‐2, IL‐4, IL‐6, IL‐7, IL‐10, and IL‐13 were measured using high‐sensitivity multiplex map human immunoassays.

No significant differences in postoperative VAS pain, swelling, and mouth opening (trismus) measures were observed between the two groups. However, the chronotherapy group had reduced overall postoperative complications compared to the control group. Regarding postoperative recovery, pain intensity scores in the chronotherapy group at 24, 48, and 72 h indicated a faster recovery than the control group. Blood samples analysis showed no statistical differences between the different inflammatory markers studied at 72 h or Day 7 in both groups.

Daytime administration of NSAIDs might be sufficient to manage postoperative pain after third molar extraction, and complications were similar between both groups.

Clinical Trial Registration: clinicaltrials. gov, Identifier database: NCT05176158.