# Diverse and Atypical Presentations of Acroangiodermatitis of Mali: Diagnostic Insights From Three Cases

**Authors:** Greeshma Peddireddy, Divya Raviprakash, Leena Dennis Joseph, Sudha Rangarajan, Adikrishnan Swaminathan

PMC · DOI: 10.7759/cureus.98861 · Cureus · 2025-12-09

## TL;DR

This paper presents three cases of acroangiodermatitis of Mali with unusual symptoms, highlighting the importance of biopsy and dermoscopy for accurate diagnosis.

## Contribution

The study emphasizes the atypical clinical presentations and the role of combined diagnostic methods in confirming acroangiodermatitis of Mali.

## Key findings

- Biopsy and dermoscopy are essential for diagnosing acroangiodermatitis of Mali.
- Venous insufficiency was confirmed in all three cases via Doppler ultrasound.
- Persistent leg lesions with vascular patterns were key clinical features.

## Abstract

Acroangiodermatitis is an uncommon, benign vasoproliferative entity that often develops in the setting of long-standing venous hypertension or arteriovenous abnormalities. Its clinical resemblance to other dermatoses often results in misdiagnosis and delayed treatment. We describe three cases, two males and one female, who presented with persistent lower limb lesions. Clinical findings included hyperpigmented plaques, indurated plaques, and erythematous soft nodules localized to the legs. Clinically, varicosities were evident in two of the three cases, and one patient had previously undergone surgical vein stripping for the same. Given the chronicity of lesions, biopsies were performed. Histopathological features were consistent with acroangiodermatitis, while dermoscopy showed vascular patterns along with white, structureless areas. Venous Doppler ultrasound confirmed the underlying venous insufficiency in all three cases. Based on clinical, dermoscopic, histopathological, and radiological evaluation, a final diagnosis of acroangiodermatitis of Mali was made. The patients were started on oral calcium dobesilate and topical corticosteroids and were referred for vascular surgical evaluation. This case series highlights the importance of recognizing the diverse and atypical presentations of acroangiodermatitis of Mali, emphasizing that biopsy and dermoscopy are critical for a definitive diagnosis.

## Linked entities

- **Chemicals:** calcium dobesilate (PubChem CID 29963)
- **Diseases:** venous insufficiency (MONDO:0000945)

## Full-text entities

- **Diseases:** dermatoses (MESH:D012871), varicosities (MESH:D014647), venous insufficiency (MESH:D014689), arteriovenous abnormalities (MESH:D001164)
- **Chemicals:** calcium dobesilate (MESH:D002123)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12784133/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12784133/full.md

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Source: https://tomesphere.com/paper/PMC12784133