# Research Progress of TNMB Staging in Lung Cancer

## TL;DR

This paper reviews the progress of TNMB staging in lung cancer, which combines anatomical and biological features for better prognosis and treatment planning.

## Contribution

The paper introduces TNMB staging as an improvement over traditional TNM by incorporating blood-based molecular markers.

## Key findings

- TNMB staging integrates blood molecular markers for a multidimensional assessment of lung cancer.
- TNMB staging shows potential for more accurate prognosis and treatment decisions compared to traditional TNM.
- Recent studies have explored various molecular markers for inclusion in the B (blood) component of TNMB staging.

## Abstract

肺癌是我国发病率和死亡率均居首位的恶性肿瘤，准确的临床分期对其预后判断和治疗策略的制定至关重要。目前国际公认的肿瘤原发灶-区域淋巴结-远处转移（tumor-nodule-metastasis, TNM）分期系统以肿瘤解剖学特征为核心，但难以反映肿瘤生物学本质。TNM-血液受累（tumor-nodule-metastasis-blood, TNMB）分期在TNM分期的基础上融入血液分子标志物，实现了解剖学与生物学特征的多维度评估，最初应用于皮肤T细胞淋巴瘤，近年逐渐拓展至肺癌领域。本文综述TNMB分期在肺癌中的现有研究应用，对比分析其与传统TNM分期在分期依据、评估维度及临床效能上的差异，并进一步总结了现有B分期相关分子标志物类型及有望纳入B分期的分子标志物。

The revised content of the 9th edition TNM staging compared with the 8th edition

Summary of relevant studies and core information on TNMB staging in lung cancer

The differences between the traditional TNM staging and TNMB staging in the diagnosis and treatment of lung cancer

Compares the molecular markers and detection methods used in the TNMB staging system in the four studies

Summary of lung cancer molecular markers