# Molecular Mechanism of Neutrophils Driving the Progression of Lung Adenocarcinoma

## TL;DR

This review explores how neutrophils contribute to the progression and spread of lung adenocarcinoma through various molecular mechanisms.

## Contribution

The paper provides a comprehensive overview of the dual roles of neutrophils and their NETs in promoting lung adenocarcinoma.

## Key findings

- Neutrophils in the tumor microenvironment differentiate into pro-tumor phenotypes.
- NETs, while initially anti-tumor, are increasingly recognized for their pro-tumor functions.
- Neutrophils influence LUAD progression through immune regulation, metabolism, and genetic mechanisms.

## Abstract

肺癌是全球发病率和死亡率最高的恶性肿瘤之一，肺腺癌（lung adenocarcinoma, LUAD）为主要类型。近年来，研究发现肿瘤微环境（tumor microenvironment, TME）在LUAD的发生发展中扮演重要角色，其中，中性粒细胞的作用日益受到关注。研究发现中性粒细胞在TME中会分化为不同表型，呈现出多重促瘤功能。此外，中性粒细胞在相关刺激下会分泌中性粒细胞胞外诱捕网（neutrophil extracellular traps, NETs），尽管NETs有一定的抗肿瘤特性，但越来越多的研究发现其有多重促肿瘤功能。本综述从免疫调控、细胞代谢、基因及多种分子机制描述了中性粒细胞在LUAD发生发展及转移中的作用。