# Research Advances on the Autophagy and Ferroptosis in the Development and Treatment of Lung Cancer

## TL;DR

This paper reviews how autophagy and ferroptosis influence lung cancer development and treatment, highlighting potential therapeutic strategies.

## Contribution

The paper systematically summarizes key signaling pathways and mechanisms linking autophagy and ferroptosis in lung cancer.

## Key findings

- NCOA4-mediated ferritinophagy and other autophagy types are critical in ferroptosis regulation.
- Non-coding RNAs and the tumor microenvironment modulate autophagy-ferroptosis interactions in lung cancer.
- Targeting autophagy-ferroptosis crosstalk offers new therapeutic potential for lung cancer treatment.

## Abstract

肺癌是严重威胁人类健康的恶性肿瘤，其发病机制复杂多样。本文系统综述自噬与铁死亡相关的信号通路和关键调控因子及其相关机制，包括核受体共激活因子4（nuclear receptor coactivator 4, NCOA4）介导的铁蛋白自噬-铁死亡轴、线粒体自噬、脂滴自噬、生物钟自噬、分子伴侣介导的自噬等，阐述肿瘤微环境与非编码RNA对肺癌的自噬-铁死亡作用。综述进一步阐述现代药物及中药活性成分通过靶向自噬和铁死亡改善肺癌的潜力，提出靶向二者的交互通路可为肺癌的治疗提供新策略。