# Regulatory T-cells in Reproductive Medicine: Implications for Endometriosis-Associated Infertility and Implantation Immunity

## TL;DR

This review explores how regulatory T-cells help maintain immune balance during pregnancy and their role in endometriosis-related infertility.

## Contribution

The paper provides a comprehensive overview of Treg biology and therapeutic potential in reproductive immunology.

## Key findings

- Treg dysfunction contributes to inflammation and lesion progression in endometriosis.
- Adoptive Treg supplementation shows promise in preclinical models for treating endometriosis.
- Tregs are essential for embryo implantation and maintaining immune homeostasis during pregnancy.

## Abstract

Regulatory T-cells (Tregs) are central to peripheral immune tolerance and act as key players that sustain the immune homeostasis required for embryo receptivity, implantation, and placentation. Treg dysfunction accelerates inflammation, angiogenesis, and lesion progression in endometriosis, whereas preclinical work indicates that adoptive Treg supplementation can restrain the advancement of endometriosis‑like lesions. Using the 2025 Nobel Prize in Physiology or Medicine scientific background as a starting point, this review summarizes Treg basic biology, roles in reproductive immunology, the pathophysiology of immune‑mediated infertility and endometriosis, and therapeutic prospects centered on Treg induction and supplementation.