# Radiation-Induced Breast Sarcoma: A Case Report and Review of the Literature

**Authors:** Kenza Bahida, Othmane Zouiten, Leila Afani, Mohamed El Fadli, Rhizlane Belbaraka

PMC · DOI: 10.7759/cureus.98827 · Cureus · 2025-12-09

## TL;DR

A rare case of breast sarcoma caused by previous radiation therapy is reported, highlighting its challenges in diagnosis and treatment.

## Contribution

A new clinical case of radiation-induced breast sarcoma is presented with insights into its diagnosis and management.

## Key findings

- A 56-year-old woman developed a sarcoma seven years after breast cancer radiotherapy.
- The case emphasizes the difficulty in diagnosing and treating radiation-induced sarcomas.

## Abstract

Radiation-induced sarcoma (RIS) of the breast is a rare but serious late complication of radiotherapy, characterized by high-grade malignancy, rapid recurrence, and poor prognosis. Although rare, its incidence may increase due to improved survival rates among breast cancer patients. We report the case of a 56-year-old woman who developed a pleomorphic undifferentiated sarcoma in the irradiated field seven years after adjuvant radiotherapy for breast cancer. This case highlights the diagnostic challenges, therapeutic considerations, and prognostic implications of this rare entity.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Diseases:** malignancy (MESH:D009369), Breast Sarcoma (MESH:D061325), RIS (MESH:D009381), undifferentiated sarcoma (MESH:D002277), breast cancer (MESH:D001943)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12782614/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12782614/full.md

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Source: https://tomesphere.com/paper/PMC12782614