# Carbapenem-Resistant Salmonella Typhi Infection in Traveler Returning to Germany from India, 2024

**Authors:** Sandra Simon, Eva Trost, Jan Lennings, Julia Enkelmann, Julia Kuhn, Michael Pietsch, Antje Flieger

PMC · DOI: 10.3201/eid3112.251234 · Emerging Infectious Diseases · 2025-12-01

## TL;DR

A traveler returning to Germany from India had a Salmonella Typhi infection resistant to multiple antibiotics, including carbapenems, raising concerns about treatment options.

## Contribution

The report highlights a new case of carbapenem-resistant Salmonella Typhi, expanding the threat of antibiotic resistance in typhoid fever.

## Key findings

- The strain was resistant to carbapenems, extended spectrum β-lactams, fluoroquinolones, and tetracyclines.
- This case underscores the growing challenge of treating typhoid fever due to extensively drug-resistant Salmonella Typhi.

## Abstract

We report on a carbapenem-, extended spectrum β-lactam-, fluoroquinolone-, and tetracycline-resistant Salmonella enterica serovar Typhi strain in a patient returning to Germany from India. Considering the recent emergence of extensively drug-resistant Salmonella Typhi strains, further expansion of antibiotic resistance to carbapenems poses a serious threat for typhoid fever treatment.

## Linked entities

- **Chemicals:** carbapenems (PubChem CID 134085)
- **Diseases:** typhoid fever (MONDO:0005619)

## Full-text entities

- **Diseases:** Salmonella Typhi Infection (MESH:D014435)
- **Chemicals:** tetracycline (MESH:D013752), Carbapenem (MESH:D015780), beta-lactam (MESH:D047090), fluoroquinolone (MESH:D024841)
- **Species:** Homo sapiens (human, species) [taxon 9606], Salmonella enterica subsp. enterica serovar Typhi (no rank) [taxon 90370]

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12782239/full.md

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Source: https://tomesphere.com/paper/PMC12782239