# Retrospective Comparison of Conventional Triple Therapy and Levofloxacin-Based Sequential Therapy for Helicobacter pylori Eradication in Mardan Medical Complex

## TL;DR

This study compared two treatments for Helicobacter pylori and found that the levofloxacin-based sequential therapy was more effective and better tolerated than the conventional triple therapy.

## Contribution

The study provides evidence supporting the use of levofloxacin-based sequential therapy over conventional triple therapy in regions with high clarithromycin resistance.

## Key findings

- Sequential therapy achieved an 80% clearance rate compared to 62% for triple therapy.
- Sequential therapy was better tolerated by patients.
- The difference in clearance rates was statistically significant (χ² = 9.03, p = 0.003).

## Abstract

Objective: This study aims to compare, using record-based data, the clearance proportions of the conventional triple management regimen and the levofloxacin-based sequential management regimen in patients treated at Mardan Medical Complex.

Methods: A record-based review was conducted from January to June 2024 among adults aged 18 to 65 years with stool antigen-confirmed Helicobacter pylori infection. Data were collected for demographics, management regimens, and post-management stool antigen results. Statistical analyses included Chi-square and independent t-tests (p < 0.05 notable).

Results: Among 238 patients, clearance was obtained in 62% of those receiving the triple management regimen and 80% of those receiving the sequential management regimen (χ² = 9.03, p = 0.003). The sequential management regimen showed greater clearance and better tolerance.

Conclusion: Sequential management regimen obtained superior clearance proportions and should be preferred in areas with high clarithromycin resistance.