# Branch Retinal Vein Occlusion Revealing Previously Undiagnosed Systemic Disease

**Authors:** Daria Valipur Kolti, Jakub Juszczyk, Sara Omidi, Julia Kierner, Dariusz Valipur Kolti

PMC · DOI: 10.7759/cureus.98675 · Cureus · 2025-12-07

## TL;DR

A case of sudden vision loss from a retinal vein block revealed hidden high blood pressure, highlighting the need for better coordination between eye doctors and general physicians.

## Contribution

Highlights BRVO as a potential first sign of undiagnosed hypertension and identifies gaps in current systemic screening protocols.

## Key findings

- BRVO can be the first clinical manifestation of undetected systemic hypertension.
- Current referral protocols for RVO lack standardization, delaying essential systemic evaluations.
- Multidisciplinary care combining ocular and systemic management is crucial to prevent complications.

## Abstract

Branch retinal vein occlusion (BRVO) is a common cause of vision loss and frequently reflects an underlying systemic vascular disorder. Early systemic assessment is fundamental for preventing ocular and cardiovascular complications. This report describes the clinical case of a 61-year-old woman who presented with sudden, painless visual field loss in the left eye. Fundoscopic and angiographic findings confirmed superotemporal BRVO with macular edema. Intravitreal anti-vascular endothelial growth factor (VEGF) therapy was initiated, and referral to a primary care physician for systemic evaluation was requested. However, due to the absence of a standardized referral protocol, the patient did not undergo prompt assessment. One week after the initial ophthalmologic visit, she presented to the emergency department with a severe headache and was found to have a hypertensive crisis. This case focuses attention on how retinal vascular occlusion (RVO) can be the first manifestation of an undetected systemic hypertension. It also marks the gaps in current systemic screening protocols for RVO and the need for closer collaboration between ophthalmologists and internal medicine specialists. A comprehensive and multidisciplinary evaluation of BRVO is indispensable for uncovering systemic risk factors and guiding treatment. Timely ocular therapy combined with systemic management can prevent irreversible visual loss and systemic complications.

## Linked entities

- **Diseases:** macular edema (MONDO:0003005)

## Full-text entities

- **Genes:** VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}
- **Diseases:** BRVO (MESH:D012170), hypertensive (MESH:D006973), ocular and cardiovascular complications (MESH:D002318), vision loss (MESH:D014786), Systemic Disease (MESH:D034721), macular edema (MESH:D008269), headache (MESH:D006261), systemic vascular disorder (MESH:D057772), RVO (MESH:D015356)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12781041/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12781041/full.md

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Source: https://tomesphere.com/paper/PMC12781041