# Enhancing translational research impact through collaborative process innovation

**Authors:** Marisha E. Palm, Sharon Phares, Gigi Hirsch

PMC · DOI: 10.1017/cts.2025.10186 · 2025-11-03

## TL;DR

This paper introduces a collaborative methodology to improve translational research by engaging multiple stakeholders in solving complex healthcare challenges.

## Contribution

The paper presents a structured, stepwise collaborative process for overcoming translational barriers through pre-competitive consortiums.

## Key findings

- Structured collaboration helps align diverse stakeholder needs in translational research.
- Innovation facilitators are crucial for successful implementation of collaborative methodologies.
- Collective skill enhancement supports capacity building in translational science.

## Abstract

Translational science methods often fall short due to the complexity of the healthcare delivery environment. We developed a methodology that involves multiple interest holders working within a pre-competitive consortium to develop solutions to translational barriers. The methodology supports innovative collaboration in a stepwise fashion: elucidating challenges, designing solutions, enabling implementation, monitoring, learning, disseminating, and catalyzing. Cases that benefit most from a structured collaborative methodology are those where diverse needs require elucidation and alignment. Application of the methodology to develop regulatory, clinical, and business innovations has shown the importance of an innovation facilitator and the capacity-building potential of collective skill enhancement.

## Full-text entities

- **Diseases:** Rheumatoid Arthritis (MESH:D001172)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12779485/full.md

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Source: https://tomesphere.com/paper/PMC12779485