# Context matters: Causality and global epidemiology of proton pump inhibitor safety

## TL;DR

This paper discusses new evidence on whether long-term use of proton pump inhibitors causes upper gastrointestinal cancer.

## Contribution

The paper introduces new causal evidence on the safety of prolonged proton pump inhibitor use.

## Key findings

- A recent study provides new evidence on the causal link between prolonged PPI use and upper gastrointestinal cancer.
- The paper highlights the importance of context in assessing the safety of proton pump inhibitors.

## Abstract

Proton pump inhibitors revolutionized acid-related disorder therapy, yet widespread overuse has raised concerns about long-term safety. A recent study in PLOS Medicine presents new evidence assessing whether links between their prolonged use and upper gastrointestinal cancer are causal.

In this Perspective, Gilaad Kaplan and Shinji Okabayashi highlight a recent study in PLOS Medicine that presents new evidence assessing whether links between prolonged proton pump inhibitor (PPI) use and upper gastrointestinal cancer are causal.