# Investigating the Role of Biomarkers in Alzheimer's Disease: A Quasi‐Experimental Study

## TL;DR

This study investigates how cognitive training and physical exercise affect cognitive performance and biomarkers in Alzheimer's patients.

## Contribution

The study introduces a community-based quasi-experimental approach to evaluate integrated cognitive and physical interventions for Alzheimer's.

## Key findings

- Cognitive performance is expected to improve with combined cognitive and physical interventions.
- Higher levels of amyloid-beta and tau proteins correlate with lower cognitive scores.
- The study emphasizes the role of community-based research in Alzheimer's therapeutic strategies.

## Abstract

Identifying biomarkers in Alzheimer's disease (AD) is essential for early diagnosis and intervention. This study explores the impact of cognitive training combined with physical exercise on cognitive performance and neurodegeneration markers in adults diagnosed with AD.

Utilizing a convenience sampling approach, we will recruit eighteen participants aged 60 and above from a local community of 150 individuals. Participants will be non‐randomly assigned to either a control group (n = 9) or an experimental group (n = 9). A quasi‐experimental design and structured interview will be conducted pre‐ and post‐intervention to assess cognitive performance (using ADAS‐Cog and MoCA) and health factors. Further more the experimental group will engage in a tailored regimen designed to enhance cognitive function and target biomarkers. Additionally statistical analyses will include t‐tests to compare cognitive scores and regression analyses to investigate the relationship between biomarker levels (amyloid‐beta >300 pg/mL and tau proteins >400 pg/mL) and cognitive performance, with significance set at p < .05.

We anticipate significant improvements in cognitive performance, with higher levels of amyloid‐beta and tau proteins correlating with lower cognitive scores.

This study aims to provide critical insights into the effectiveness of integrated cognitive and physical interventions in addressing cognitive decline in AD, emphasizing the importance of community‐based research in developing future therapeutic strategies.