# Generalized coarsened confounding for causal effects: a large-sample framework

**Authors:** Debashis Ghosh, Lei Wang

PMC · DOI: 10.1515/jci-2025-0002 · 2026-01-12

## TL;DR

This paper introduces a new framework for handling confounding in causal inference using generalized coarsened procedures and provides theoretical guarantees for the methods.

## Contribution

The paper introduces two new algorithms and a general asymptotic framework for generalized coarsened confounding.

## Key findings

- The proposed framework provides asymptotic results for the average causal effect estimator.
- Conditions for consistency and an asymptotic justification for variance formulae are established.
- A bias correction technique is introduced and applied to real observational data.

## Abstract

There has been widespread use of causal inference methods for the rigorous analysis of observational studies and to identify policy evaluations. In this article, we consider a class of generalized coarsened procedures for confounding. At a high level, these procedures can be viewed as performing a clustering of confounding variables, followed by treatment effect and attendant variance estimation using the confounder strata. In addition, we propose two new algorithms for generalized coarsened confounding. While previous authors have developed some statistical properties for one special case in our class of procedures, we instead develop a general asymptotic framework. We provide asymptotic results for the average causal effect estimator as well as providing conditions for consistency. In addition, we provide an asymptotic justification for the variance formulae for coarsened exact matching. A bias correction technique is proposed, and we apply the proposed methodology to data from two well-known observational studies.

## Full-text entities

- **Genes:** CD46 (CD46 molecule) [NCBI Gene 4179] {aka AHUS2, MCP, MIC10, TLX, TRA2.10}
- **Diseases:** Cancer (MESH:D009369), COVID19 (MESH:D000086382), RHC (MESH:D006333), death (MESH:D003643)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

50 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12777950/full.md

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Source: https://tomesphere.com/paper/PMC12777950