# Bilateral Parotid Gland Cysts as an Atypical Indicator of Sjögren's Syndrome: A Case Study and Literature Overview

**Authors:** Stefania Troise, Giuseppe Tarallo, Emanuele Carraturo, Fabio Di Blasi, Marco Sarcinella, Maria Esposito, Federica Calabria, Iaquino Vincenzo, Giovanni Dell’Aversana Orabona

PMC · DOI: 10.22038/ijorl.2025.85419.3869 · 2025-01-01

## TL;DR

A case study shows that cysts in the parotid glands can be a rare sign of Sjögren's syndrome, a condition that affects moisture-producing glands.

## Contribution

This case highlights an atypical clinical presentation of Sjögren's syndrome involving bilateral parotid gland cysts.

## Key findings

- Bilateral parotid gland cysts were found in a patient with late-stage Sjögren's syndrome.
- Diagnostic tests ruled out malignancy and other common cystic conditions.
- MRI showed fluid-filled nodules in both parotid glands.

## Abstract

Sjögren's syndrome is a systemic autoimmune disorder that gradually impairs exocrine function, primarily affecting lacrimal and salivary glands.

We describe an unusual presentation involving an elderly female patient diagnosed with late-stage Sjögren's syndrome. Laboratory testing eliminated viral infections including HIV and HCV. Fine-needle aspiration biopsy of parotid swellings revealed inflammatory cystic lesions, excluding malignancy and other common cystic conditions. MRI revealed several fluid-filled nodules in both glands.

This report supports including Sjögren's syndrome in the differential diagnosis for bilateral cystic lesions of the parotid glands. A synthesis of similar literature cases is included.

## Full-text entities

- **Diseases:** systemic autoimmune disorder (MESH:D020274), Sjogren's Syndrome (MESH:D012859), malignancy (MESH:D009369), viral infections (MESH:D014777), Parotid Gland Cysts (MESH:D010309), cystic lesions of the parotid glands (MESH:D010305), inflammatory cystic lesions (MESH:D018297), Bilateral (MESH:D006312)
- **Species:** Human immunodeficiency virus 1 (no rank) [taxon 11676], Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12777673/full.md

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Source: https://tomesphere.com/paper/PMC12777673