Intradermal hepatitis B vaccination with imiquimod pretreatment in dialysis patients: a cost-effectiveness analysis

TL;DR

This study finds that a specific hepatitis B vaccination method with imiquimod is cost-effective for dialysis patients.

Contribution

The study introduces a cost-effective vaccination strategy for dialysis patients using intradermal HBV Sci-B-Vac with imiquimod pretreatment.

Findings

The IMQ + ID group had the highest QALYs (2.9763) compared to other groups.

The ICER of the IMQ + ID group was below the willingness-to-pay threshold of 50,000 USD/QALY.

The IMQ + ID group had an 85.06% probability of being cost-effective at the WTP threshold.

Abstract

Dialysis patients are at high risk for hepatitis B virus (HBV) infection. Intramuscular administration of HBV vaccination has shown limited responsiveness and durability of seroprotection in dialysis patients. Intradermal (ID) HBV Sci-B-Vac vaccination with imiquimod (Toll-like receptor 7 agonist) pretreatment was reported to be safe and improve seroprotection. This study aimed to evaluate the cost-effectiveness of ID administration of HBV Sci-B-Vac with pre-treatment imiquimod cream in dialysis patients from the perspective of US healthcare providers.

A lifetime Markov model was used to estimate outcomes in a hypothetical cohort of serologically negative dialysis patients with: (1) HBV Sci-B-Vac administered intradermally with pre-treatment imiquimod (IMQ) cream (IMQ + ID group), (2) HBV Sci-B-Vac by intradermal injection alone (ID group), and (3) HBV Sci-B-Vac by intramuscular injection alone (IM group). Main results included direct medical costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio (ICER).

QALYs in the IMQ + ID group (2.9763) were the highest, followed by the ID group (2.9751) and the IM group (2.9740). The ID group (more costly and totals less QALYs versus IMQ + ID) was strongly dominated by the IMQ + ID group, and was eliminated from the cost-effectiveness analysis. The ICER of the IMQ + ID group versus the IM group (17,032 USD/QALY) was lower than the willingness-to-pay (WTP) threshold (50,000 USD/QALY) and remained lower than the WTP threshold in the one-way sensitivity analysis. The probabilities of IMQ + ID, IM, and ID groups to be cost-effective at a WTP of 50,000 USD/QALY were 85.06%, 14.86%, and 0.08%, respectively.

ID administration of HBV Sci-B-Vac with pre-treatment IMQ cream in serologically negative dialysis patients was the cost-effective strategy.

The online version contains supplementary material available at 10.1186/s12962-025-00682-0.

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