# Exercise intervention regulates gut microbiota to improve type 2 diabetes: a narrative review of the mechanisms

## TL;DR

Exercise can improve type 2 diabetes by changing gut bacteria, which helps control blood sugar and metabolism.

## Contribution

This review identifies how exercise modulates gut microbiota to improve T2DM through multiple physiological pathways.

## Key findings

- Exercise alters gut microbiota composition and function, improving insulin sensitivity.
- Mechanisms include bile acid metabolism, short-chain fatty acid production, and LPS reduction.
- Exercise effects depend on intensity, duration, and type, suggesting personalized regimens.

## Abstract

The gut microbiota is increasingly recognized as a key factor in the pathogenesis of type 2 diabetes mellitus (T2DM). Concurrently, exercise intervention has emerged as a promising non-pharmacological strategy for T2DM management, potentially mediated through gut microbiome modulation.

This narrative review searched Web of Science, PubMed, and Embase for literature published from 1992 to the present, ultimately including 58 relevant publications. The focus was on elucidating the physiological mechanisms by which exercise modulates gut microbiota to ameliorate T2DM.

Our synthesis indicates that exercise training beneficially alters gut microbiota composition and function, which in turn enhances systemic insulin sensitivity and improves metabolic disturbances in T2DM. These improvements are mediated through multiple pathways, including bile acid metabolism, short-chain fatty acid production, lipopolysaccharide reduction, and branched chain amino acid catabolism. The effects of exercise on the gut microbiome are influenced by factors such as exercise intensity, duration, and type, suggesting the need for individualized regimens.

Exercise intervention improves T2DM by modulating gut microbiota via several mechanistic pathways. Future research should prioritize personalized exercise prescriptions, larger sample sizes, integrated multi-omics approaches, and exploration of combined interventions with diet or medication to optimize T2DM prevention and treatment.