Demystifying anti-inflammatory therapeutic strategies against pancreatitis and concomitant diseases: a 2025 perspective
Mengli Yue, Sibtain Muhammad, Song Jiang, Madappa C Maridevaru, Yinghe Zhang, Bing Guo, Pi Liu
TL;DR
This review explores new anti-inflammatory treatments for pancreatitis and related diseases, emphasizing targeted delivery and multimodal strategies for better patient outcomes.
Contribution
The paper introduces recent advancements in anti-inflammatory therapies, including nanotechnology and multitargeted approaches, for pancreatitis and its complications.
Findings
Nanocarrier-based systems improve targeted delivery of anti-inflammatory agents, enhancing efficacy and reducing side effects.
Gas-based therapies, gene therapy, and probiotics show potential in treating pancreatitis and related conditions.
Personalized, multimodal strategies are needed to address treatment challenges like stability and immune response modulation.
Abstract
Pancreatitis is a complex, progressive inflammatory disorder that often transitions from acute to chronic stages, leading to significant comorbidities such as diabetes, cardiovascular diseases, and bone disorders. These complications complicate treatment strategies, highlighting the need for more targeted approaches. Historically, therapeutic strategies have focused on mechanisms addressing immune dysregulation, oxidative stress, and tissue damage. However, recent advancements have focused on anti-inflammatory mechanisms as primary therapeutic targets for pancreatitis and its associated conditions, as anti-inflammatory treatments help in alleviating chronic inflammation, minimizing tissue damage, and inhibiting disease progression, thereby enhancing recovery and overall patient well-being. This review highlights the most recent advancements in anti-inflammatory therapies for…
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Taxonomy
TopicsPancreatitis Pathology and Treatment · Pancreatic and Hepatic Oncology Research · Phagocytosis and Immune Regulation