Nanotechnology-donated ischemic stroke therapeutics: evolving strategies from the basic to the cutting-edge
Yuting Wang, Jiaxu Xu, Wenxuan Yan, Shenwu Zhang, Cong Luo, Yuequan Wang
TL;DR
This paper reviews how nanotechnology is being used to improve treatments for ischemic stroke by enhancing drug delivery and targeting.
Contribution
The paper highlights the latest advancements in nanodrug delivery systems for ischemic stroke therapy.
Findings
Nanodrug delivery systems can improve drug efficacy and BBB penetration.
Thrombus- and lesion-targeted nano-DDS offer precise treatment for ischemic stroke.
Biomimetic and exosome-based nanotherapeutics show promising potential.
Abstract
Ischemic stroke (IS) is accompanied by high disability and mortality. Thrombolysis and neuroprotection are the predominant therapeutic strategies for IS. However, thrombolytic drugs commonly suffer from hemorrhagic risks and unsatisfactory thrombus-targeting delivery. Additionally, the blood-brain barrier (BBB) presents a significant challenge for the effective delivery of neuroprotective drugs. In recent years, nanodrug delivery systems (nano-DDS) have garnered significant attention for their ability to improve drug efficacy in vivo and facilitate BBB penetration. Specifically, thrombus- and cerebral ischemic lesion-targeted nano-DDS have emerged as a versatile toolbox for the precise treatment of IS. Herein, this paper provides an overview on the latest advancements in nano-DDS for IS therapy, covering conventional nanomedicines, cell membrane-camouflaged biomimetic nano-DDS, and…
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Taxonomy
TopicsExtracellular vesicles in disease · Nanoparticle-Based Drug Delivery · Neuroinflammation and Neurodegeneration Mechanisms