Multifunctional carboxymethyl cellulose-based hydrogels with zwitterionic and silver nanowire components for wound management
Kit-Leong Cheong, Te Pan, Suresh Veeraperumal, Franck Quero, Gowsika Jaikumar, Timo Kikas, Malairaj Sathuvan, Karsoon Tan, Saiyi Zhong, Udayakumar Veerabagu
TL;DR
Researchers developed a new type of wound dressing using hydrogels with silver nanowires that help fight infection, support healing, and manage moisture in chronic wounds.
Contribution
A novel zwitterionic hydrogel with silver nanowires was created for enhanced chronic wound management.
Findings
The hydrogels showed strong antibacterial and antioxidant activity with low cytotoxicity.
In vivo experiments revealed accelerated wound closure and enhanced tissue regeneration.
Hydrogels promoted M2 macrophage polarization, supporting pro-healing responses.
Abstract
Chronic wounds represent a major global health burden, while conventional dressings often fail to meet the complex requirements of chronic wound management, including infection control, moisture balance, and tissue regeneration. In this study, two multifunctional zwitterionic hydrogels—vinylpyridine carboxybetaine/sulfobetaine/silver nanowire/carboxymethyl cellulose (VCS/Ag/CMC) and acrylamide carboxybetaine/sulfobetaine/silver nanowire/carboxymethyl cellulose (ACS/Ag/CMC) – were synthesized. Structural analyses confirmed the successful incorporation of aromatic or aliphatic zwitterionic components and uniform distribution of silver nanowires within the CMC-based hydrogel networks. Both hydrogels exhibited favorable mechanical strength, high swelling capacity, controlled degradability, and sustained silver release, providing a balanced profile for chronic wound applications. In vitro…
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Taxonomy
TopicsWound Healing and Treatments · Hydrogels: synthesis, properties, applications · Tissue Engineering and Regenerative Medicine