# Isocitrate dehydrogenase 1 mutations drive downregulation of IL1R1 and dysregulated inflammatory response in acute myeloid leukemia

**Authors:** Sophie Steinhäuser, Thomas Beder, Emely Hübner, Dorothea S. Feuereisel, Jonathan Jebens, Nadine Wolgast, Muhammed Bilal Karaca, Kathrin Richter, Nina Hedemann, Britta Steer, Miriam Denker, Sonja Bendig, Monika Brüggemann, Patricia Silva, Lars Fransecky, Martin Neumann, Friedrich Stölzel, Alina M. Hartmann, Timo Gemoll, Lorenz Bastian, Claudia D. Baldus, Simone Lipinski

PMC · DOI: 10.1038/s41408-025-01445-z · 2026-01-06

## Full-text entities

- **Genes:** IL1R1 (interleukin 1 receptor type 1) [NCBI Gene 3554] {aka CD121A, CRMO3, D2S1473, IL-1R-alpha, IL-1RT1, IL1R}
- **Diseases:** acute myeloid leukemia (MESH:D015470), inflammatory (MESH:D007249)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12775398/full.md

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Source: https://tomesphere.com/paper/PMC12775398