Oroxylin A From Scutellaria baicalensis Improved Pulmonary Fibrosis of Radiation Pneumonia Through Ferroptosis by Nrf2
Wei Zhang, Wen Hao, Xiaoxia Gao, Kuo Li
TL;DR
Oroxylin A, a compound from Scutellaria baicalensis, reduces lung fibrosis caused by radiation pneumonia by targeting ferroptosis and the Nrf2 pathway.
Contribution
The study reveals a novel mechanism by which Oroxylin A mitigates radiation-induced lung fibrosis through ferroptosis inhibition and Nrf2 activation.
Findings
Oroxylin A reduced oxidative stress and improved pulmonary fibrosis in a radiation pneumonia model.
Oroxylin A suppressed ferroptosis and increased Nrf2 protein expression in liver cells.
Nrf2 inhibition diminished the protective effects of Oroxylin A, confirming its role in the mechanism.
Abstract
Radiation pneumonitis can result in respiratory dysfunction and progress to radiation fibrosis, and in severe cases, respiratory failure may occur. Hence, we investigated the effects of Oroxylin A from Scutellaria baicalensis in radiation pneumonia (RP) and the underlying mechanism. Oroxylin A improved pulmonary fibrosis, reduced oxidative stress, and promoted cell growth in model of RP. Oroxylin A suppressed ferroptosis and induced Nrf2 protein expressions in liver cells of model of RP. Moreover, Nrf2 inhibitor reduced the effects of Oroxylin A on pulmonary fibrosis in model of RP by oxidative stress. Collectively, these data suggest that Oroxylin A from Scutellaria baicalensis improved pulmonary fibrosis of RP through ferroptosis by Nrf2 axle.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29
Figure 30
Figure 31
Figure 32
Figure 33
Figure 34
Figure 35
Figure 36
Figure 37
Figure 38
Figure 39
Figure 40
Figure 41
Figure 42
Figure 43
Figure 44
Figure 45
Figure 46
Figure 47
Figure 48
Figure 49
Figure 50Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsFerroptosis and cancer prognosis · Flavonoids in Medical Research · Clusterin in disease pathology