# A Rare Case of Gastric Glomangioma Mimicking a Gastrointestinal Stromal Tumor (GIST)

**Authors:** Ahmet Yugruk, Altan Aydın, Orhan Semerci

PMC · DOI: 10.7759/cureus.98666 · Cureus · 2025-12-07

## TL;DR

A rare case of gastric glomangioma was mistaken for a gastrointestinal stromal tumor, highlighting the need for accurate diagnosis in similar cases.

## Contribution

This paper reports a rare clinical case of gastric glomangioma misdiagnosed as a gastrointestinal stromal tumor.

## Key findings

- A gastric glomangioma was surgically excised and confirmed histopathologically in a 61-year-old woman.
- The lesion was initially misdiagnosed as a gastrointestinal stromal tumor due to overlapping imaging features.
- Complete surgical removal resulted in an uneventful recovery with no complications during follow-up.

## Abstract

Glomus tumors are rare mesenchymal neoplasms originating from modified smooth muscle cells involved in thermoregulation. Although typically located in peripheral soft tissues, their presence in the stomach is uncommon and may lead to diagnostic difficulties. This report presents a rare case of gastric glomangioma that clinically and radiologically mimicked a gastrointestinal stromal tumor. A 61-year-old woman presented in July 2024 with a three-month history of epigastric pain, nausea, and abdominal bloating. Upper gastrointestinal endoscopy revealed a submucosal lesion at the incisura angularis resembling a stromal tumor. Endoscopic ultrasonography demonstrated a well-circumscribed, submucosal, iso-hypoechoic mass measuring 19.5×11.3 mm. Due to persistent symptoms, surgical excision was performed, and the mass was completely removed with negative margins. Histopathological evaluation confirmed the diagnosis of a gastric glomus tumor. The postoperative course was uneventful, and no complications were observed during follow-up. This case emphasizes the importance of including glomus tumors in the differential diagnosis of subepithelial gastric lesions, particularly when imaging findings overlap with more common entities. Increased clinical awareness may improve preoperative diagnostic accuracy and support appropriate management strategies.

## Linked entities

- **Diseases:** gastrointestinal stromal tumor (MONDO:0011719)

## Full-text entities

- **Diseases:** Gastric Glomangioma (MESH:D005918), gastric lesions (MESH:D013272), mesenchymal neoplasms (MESH:D009369), abdominal bloating (MESH:D000007), GIST (MESH:D046152), nausea (MESH:D009325), epigastric pain (MESH:D010146)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12775170/full.md

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Source: https://tomesphere.com/paper/PMC12775170