# Non-contact lung disease classification via orthogonal frequency division multiplexing-based passive 6G integrated sensing and communication

**Authors:** Hasan Mujtaba Buttar, Muhammad Mahboob Ur Rahman, Muhammad Wasim Nawaz, Adnan Noor Mian, Adnan Zahid, Qammer H. Abbasi

PMC · DOI: 10.1038/s43856-025-01181-2 · Communications Medicine · 2026-01-06

## TL;DR

This study explores using 6G/WiFi radio signals to screen for five lung diseases non-invasively, with high accuracy using machine learning.

## Contribution

A novel contactless diagnostic method using 6G/WiFi signals and deep learning for multi-disease respiratory screening.

## Key findings

- A convolutional neural network achieved 98% accuracy in classifying five respiratory diseases from radio signal data.
- Reliable screening is possible using only 12.5% of the total bandwidth, enabling dual sensing and communication.
- The method shows promise for low-cost, real-time diagnostics in resource-limited settings.

## Abstract

The screening tools for respiratory diseases typically involve spirometry (for asthma and COPD), CT scans (for interstitial lung disease), chest X-rays (for pneumonia and tuberculosis), and sputum analysis (for tuberculosis).

This work examines a diagnostic approach whereby a subject’s chest is radio-exposed to non-ionizing 6G/WiFi multi-carrier radio signals at a frequency of 5.23 GHz. The fact that each respiratory disease modulates the amplitude, frequency, and phase of each radio frequency differently allows us to screen for five respiratory diseases: asthma, chronic obstructive pulmonary disease, interstitial lung disease, pneumonia, and tuberculosis. We collect a new dataset (OFDM-Breathe) from 220 individuals in a hospital setting, including 190 patients and 30 healthy controls. The dataset contains over 26,000 s of radio signal recordings across 64 frequencies. Several machine learning and deep learning models are evaluated to classify disease type based on the discriminatory signatures of radio signals.

We learn that a vanilla convolutional neural network achieves 98% accuracy in differentiating between the five respiratory diseases, along with strong performance in precision, recall, and F1-score. An ablation study demonstrates that reliable screening with up to 96% accuracy is possible using only eight frequencies, representing just 12.5% of the total bandwidth and leaving 87.5% available for 6G/WiFi data communication.

The proposed method could enable real-time respiratory disease screening, could help realize the health equity in developing countries, and lays the groundwork for 6G/WiFi-enabled integrated sensing and communication platforms for healthcare systems of the future.

This study explores a non-ionizing, contactless screening method for five prevalent lung diseases using 6G/WiFi radio signals (to complement the conventional methods such as chest X-rays, spirometry, CT scans). It leverages the fact that each lung disease leads to an abnormal breathing pattern which in turn alters the reflected signals in a unique way. Data from 220 individuals (both healthy and patients) were collected in a clinical setting, and AI models were trained to distinguish between disease-specific patterns. The approach demonstrated high accuracy in detecting respiratory conditions and holds promise as a low-cost diagnostic tool, especially in remote or resource-limited settings (such as in developing countries). The findings also highlight the potential of 6G/WiFi signals for broader health diagnostics.

Buttar et al. explore a contactless method for screening five respiratory diseases using 6G Integrated Sensing And Communication Orthogonal Frequency Division Multiplexing (ISAC OFDM) signals from software-defined radios. Using deep learning, the approach enables accurate, real-time screening for Asthma, Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease, Pneumonia and Tuberculosis.

## Linked entities

- **Diseases:** asthma (MONDO:0004979), chronic obstructive pulmonary disease (MONDO:0005002), interstitial lung disease (MONDO:0015925), pneumonia (MONDO:0005249), tuberculosis (MONDO:0018076)

## Full-text entities

- **Diseases:** interstitial lung disease (MESH:D017563), COPD (MESH:D029424), asthma (MESH:D001249), tuberculosis (MESH:D014376), pneumonia (MESH:D011014), respiratory disease (MESH:D012140), Non-contact lung disease (MESH:D008171)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12774925/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12774925/full.md

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Source: https://tomesphere.com/paper/PMC12774925