# RETRACTION: miR‐709 Up‐Regulated in Hepatocellular Carcinoma, Promotes Proliferation and Invasion by Targeting GPC5

PMC · DOI: 10.1111/cpr.70151 · Cell Proliferation · 2025-12-02

## TL;DR

This retracted paper claimed that miR-709 promotes liver cancer growth by targeting GPC5, but duplicated figures led to loss of confidence in the results.

## Contribution

The paper originally reported miR-709's role in hepatocellular carcinoma by targeting GPC5, but was retracted due to duplicated figures.

## Key findings

- miR-709 was found to be up-regulated in hepatocellular carcinoma.
- The study claimed miR-709 promotes cancer cell proliferation and invasion by targeting GPC5.
- The paper was retracted due to duplicated figures and unreliable results.

## Abstract

RETRACTION: 
LiuT.
, 
ZhangX.
, 
ShaK.
, 
LiuX.
, 
ZhangL.
 and 
WangB.
, “miR‐709 Up‐Regulated in Hepatocellular Carcinoma, Promotes Proliferation and Invasion by Targeting GPC5,” Cell Proliferation
48, no. 3 (2015): 330–337, 10.1111/cpr.12181.25818666
PMC6495981

The above article, published online on 27 March 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Qi Zhou; and John Wiley & Sons Ltd. The retraction has been agreed upon following the identification of duplicated elements between Figures 5c and 7c, which were reported to represent different experimental conditions. The authors provided some supporting data; however, it was insufficient to fully address the concerns. As a result, the editors have lost confidence in the reliability of the results. The authors did not respond when asked to agree to the final wording of the retraction.

## Linked entities

- **Genes:** Mir709 (microRNA 709) [NCBI Gene 735271], GPC5 (glypican 5) [NCBI Gene 2262]
- **Diseases:** Hepatocellular Carcinoma (MONDO:0007256)

## Full-text entities

- **Genes:** GPC5 (glypican 5) [NCBI Gene 2262]
- **Diseases:** Hepatocellular Carcinoma (MESH:D006528)

## Full text

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Source: https://tomesphere.com/paper/PMC12774618