# Ovarian Aging: A Multifaceted Perspective on Mechanisms

**Authors:** Xiaoqing Zhang, Xinyi Dong, Xue Zhang, Suying Yuan, Qiran Zhang, Zilu Guo, Xiaoxue Yang, Qionghua Wang, Tianlan Yang, Donghui Huang

PMC · DOI: 10.1111/cpr.70144 · Cell Proliferation · 2025-11-04

## TL;DR

This paper explores how mitochondrial dysfunction connects various biological processes involved in ovarian aging.

## Contribution

It introduces a mechanistic network linking mitochondrial dysfunction to genetic, metabolic, and inflammatory pathways in ovarian aging.

## Key findings

- Mitochondrial dysfunction is identified as a central hub in ovarian aging.
- Genetic, metabolic, and inflammatory pathways are interconnected through mitochondrial processes.
- The network provides a comprehensive view of aging mechanisms in the ovary.

## Abstract

A mechanistic network of ovarian aging, highlighting mitochondrial dysfunction as a central hub interconnected with genetic, metabolic, and inflammatory pathways.

## Full-text entities

- **Diseases:** mitochondrial dysfunction (MESH:D028361), inflammatory (MESH:D007249), Aging (MESH:D019588)

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12774617/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12774617/full.md

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Source: https://tomesphere.com/paper/PMC12774617