# Long-Term Outcome of Myocardial Protection in Heart Transplantation: Comparison Among 3 Different Solutions

## TL;DR

This study compares the long-term outcomes of three different cardioplegic solutions used in heart transplants and finds that one solution is linked to higher graft dysfunction but similar survival rates.

## Contribution

The study provides new long-term comparative data on cardioplegic solutions in heart transplantation.

## Key findings

- HTK-Custodiol was associated with higher primary graft dysfunction compared to Celsior.
- In-hospital mortality and long-term survival were similar across all three groups.
- Post-transplant rejection rates were comparable among the three cardioplegic solutions.

## Abstract

We analysed our long-term experience with heart transplantation (Htx) utilizing 3 different cardioplegic solutions.

During a 20-year period, 538 adult individuals underwent isolated Htx at our institution. Ten cases in which the Organ Care System TransMedics Inc was utilized were excluded, resulting in a final cohort of 528 individuals. Patients were stratified into 3 groups according to the donor heart cardioplegic solution: Celsior (n = 301; reference group), HTK-Custodiol (n = 88), and St Thomas (n = 139). Mean follow-up period was 6.2 ± 5.5 years (maximum 20 years).

The rate of severe primary graft dysfunction (PGD) was 10.2% in the HTK-Custodiol group, significantly higher than the reference group (4.5%; P < .040). Overall, in-hospital mortality was 12.9%: 13.6% in the HTK-Custodiol group and 12.9% in the St Thomas group, comparable to the reference group (P = .803 and P = .924). Survival at 1, 5, and 12 years in the Celsior and HTK-Custodiol groups was 82.6 ± 2.2% vs 85.2±3.8%, 79.4 ± 2.4% vs 82.1 ± 4.3%, and 66.8 ± 3.3% vs 62.9 ± 7.3%, respectively (P = .706). Survival at 1, 5, and 12 years in the St Tomas group was 81.5 ± 3.4%, 71.9 ± 4.1%, and 65.5 ± 5.2%, respectively, comparable to the reference group (P = .640). Post-transplant rejection rate was similar among the groups.

The use of HTK-Custodiol solution was associated with a significantly higher incidence of PGD when compared to Celsior solution, although this data had no impact on in-hospital mortality. Long-term survival and post-transplant rejection were comparable among the 3 groups. HTK-Custodiol solution should be used with caution for preservation of donor hearts.

215-29042020; May 5, 2020.

Heart transplantation (HTx) has become the preferred option for select end-stage heart failure patients.