Retraction: NAD(P)H: Quinone oxidoreductase 1 deficiency conjoint with marginal vitamin C deficiency causes cigarette smoke induced myelodysplastic syndromes

Abstract

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After this article [1] was published, concerns were raised regarding results presented in Figs 3, 4, S1, and S2, and in Table S2.

Specifically:

Regarding Fig 3A, the first author stated the 21 Days 15 mg vit C TUNEL panel is incorrect.

The first author stated they agree with the concerns for the α-tubulin panels in Figs 3G, 4A, and S1A. They stated that an error occurred in the figure preparation and that Fig 4A α-tubulin is incorrect and provided a replacement panel.

Regarding the marker lanes in Fig 4 in [1] and Figs 2 and 6 in [2], the first author stated these lanes are similar because the experiments were run under similar percentage SDS-PAGE and the same voltage, and the protein marker is shown for reference only. They provided data underlying Figs 4A and 4B, however editorial review raised additional concerns about the integrity of the underlying data provided.

The first author provided incomplete underlying data for Figs 3, 4, S1, S2 and Table S2. These data did not resolve the above concerns, and PLOS identified additional concerns with the provided data underlying Table S2.

In light of the above concerns that question the reliability of the reported results, the PLOS One Editors retract this article.

AD did not agree with the retraction. ND, AG, and TD either did not respond directly or could not be reached. IBC is deceased.