# Effects of Two Anti‐HIV‐1 Regimens on Creatinine and Blood Lipids in Elderly People Living With HIV‐1

## TL;DR

This study compares two HIV treatments in elderly patients, finding that one causes fewer lipid issues and better BMI control.

## Contribution

The study provides new evidence on the comparative safety of ANV and EFV regimens for elderly HIV patients.

## Key findings

- ANV regimen showed lower triglycerides abnormality compared to EFV.
- ANV group had fewer abnormal BMI cases in those aged 66 and above.
- Both regimens caused minimal kidney damage in elderly HIV patients.

## Abstract

Elderly people living with HIV‐1 (PLWH) are more prone to HIV‐related complications.

We investigated the creatinine and blood lipids of 153 PLWHs receiving an ANV regimen and 315 PLWHs receiving an EFV regimen.

The results showed that the abnormal rates of creatinine were very low in both groups, and ANV had a lower triglycerides abnormality than EFV. No evident difference in high‐density lipoprotein, low‐density lipoprotein, and total cholesterol was observed between the two groups. The abnormal body mass index of the ANV group aged 66 and above was much less than that of the EFV group.

Both the ANV and EFV regimens did not cause severe kidney damage. ANV had an advantage in controlling dyslipidemia. We strongly recommend elderly PLWHs to choose the ANV regimen.