# Postoperative anaemia: the unseen challenge in cardiac surgery

**Authors:** Matthew A. Warner, Jacob Raphael

PMC · DOI: 10.1016/j.bjao.2025.100514 · BJA Open · 2025-12-17

## TL;DR

Postoperative anemia after cardiac surgery is a significant issue that can be managed with IV iron treatment, but more research is needed to confirm its effectiveness.

## Contribution

The paper highlights the need for large-scale trials to evaluate the efficacy of intravenous iron treatment for postoperative anemia.

## Key findings

- Postoperative anemia is linked to poor clinical outcomes in cardiac surgery patients.
- IV iron treatment may improve hemoglobin recovery and reduce transfusion use.
- More robust trials are required to validate treatment benefits on patient outcomes.

## Abstract

Postoperative anaemia is an overlooked complication of cardiac surgery that is associated with adverse clinical outcomes. Although small clinical trials suggest that postoperative treatment with i.v. iron improves haemoglobin recovery and reduces transfusion utilisation, appropriately powered randomised controlled trials are necessary to definitively evaluate the efficacy of treatment on clinical outcomes of importance to patients, clinicians, and healthcare systems. A comprehensive approach to perioperative anaemia management demands a renewed focus on both prevention and treatment to improve patient outcomes.

## Linked entities

- **Diseases:** anemia (MONDO:0002280)

## Full-text entities

- **Diseases:** Postoperative anaemia (MESH:D000743)
- **Chemicals:** iron (MESH:D007501)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12771333/full.md

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Source: https://tomesphere.com/paper/PMC12771333