# DiaNat-DB-v2: A Molecular Database of Antidiabetic Compounds from Medicinal Plants and Functional Foods

## TL;DR

DiaNat-DB-v2 is an updated database of antidiabetic compounds from plants and foods, offering new opportunities for drug discovery and dietary interventions.

## Contribution

The database integrates medicinal plant and food-derived compounds, showing minimal overlap with FDA-approved drugs and high originality.

## Key findings

- DiaNat-DB-v2 contains unique molecular scaffolds with minimal overlap with FDA-approved drugs.
- The database has high natural-product likeness and low structural alerts, indicating safety potential.
- It supports both drug discovery and nutrition research with diverse chemical space coverage.

## Abstract

Diabetes mellitus
continues to be a significant health
problem
worldwide, and effective strategies and resources for its prevention
and treatment are needed. Here, we present DiaNat-DB-v2, a refined
and expanded version of the compound database that incorporates newly
identified antidiabetic compounds from medicinal plants. By incorporating
food-derived compounds, DiaNat-DB-v2 bridges the gap between medicinal
chemistry and functional food research, creating new opportunities
for nutraceutical development, personalized dietary interventions,
and drug discovery. A comprehensive analysis of structural content,
diversity, chemical space coverage, and safety-related metrics revealed
that the updated database exhibits minimal overlap with FDA-approved
drugs and contains a large proportion of unique molecular scaffolds,
underscoring its originality and complementarity. Furthermore, the
database has high natural-product likeness, a low incidence of structural
alerts, and moderate compliance with classical druglikeness criteria.
Together, these findings emphasize the value of DiaNat-DB-v2 as a
resource for both health-oriented compound discovery and nutrition-focused
research. DiaNat-DB-v2 is freely accessible as Supporting Information.