# Artificial intelligence software to detect small hepatic lesions on hepatobiliary-phase images using multiscale sampling

## TL;DR

This study shows that AI software improves the detection of small liver lesions in medical images, especially when used correctly.

## Contribution

A novel AI method using multiscale sampling improves detection of small hepatic lesions in hepatobiliary-phase imaging.

## Key findings

- AI software significantly improved lesion localization for all readers.
- Improvement was observed even for lesions smaller than 6 mm.
- Readers with low false-positive rates saw better overall diagnostic performance with AI.

## Abstract

To investigate the effect of multiscale sampling artificial intelligence (msAI) software adapted to small hepatic lesions on the diagnostic performance of readers interpreting gadoxetic acid-enhanced hepatobiliary-phase (HBP) images.

HBP images of 30 patients harboring 186 hepatic lesions were included. Three board-certified radiologists, 9 radiology residents, and 2 general physicians interpreted HBP image data sets twice, once with and once without the msAI software at 2-week intervals. Jackknife free-response receiver-operating characteristic analysis was performed to calculate the figure of merit (FOM) for detecting hepatic lesions. The negative consultation ratio (NCR), percentage of correct diagnoses turning into incorrect by the AI software, was calculated. We defined readers whose NCR was lower than 10% as those correctly diagnosed the false findings presented by the software.

The msAI software significantly improved the lesion localization fraction (LLF) for all readers (0.74 vs 0.82, p < 0.01); the FOM did not (0.76 vs 0.78, p = 0.45). In lesion-size-based subgroup analysis, the LLF (0.40 vs 0.53, p < 0.01) improved significantly with the AI software even for lesions smaller than 6 mm, whereas the FOM (0.63 vs 0.66, p = 0.51) showed no significant difference. Among 10 readers with an NCR lower than 10%, not only the LLF but also the FOM were significantly better with the software (LLF 0.77 vs 0.82, FOM 0.79 vs 0.84, both p < 0.01).

The detectability of small hepatic lesions on HBP images was improved with msAI software especially when its results were properly evaluated.