# An invasive Aspergillus flavus infection in an extremely preterm neonate: a case report

**Authors:** Neema Pithia, Margie Morgan, Thea Tagliaferro, Priya R. Soni

PMC · DOI: 10.1016/j.mmcr.2025.100757 · Medical Mycology Case Reports · 2025-12-11

## TL;DR

This paper reports a fatal fungal infection in a 25-week-old preterm infant caused by Aspergillus flavus and emphasizes the importance of early detection and treatment.

## Contribution

The paper presents a rare clinical case of invasive Aspergillus flavus infection in an extremely preterm neonate.

## Key findings

- The infection was fatal despite antifungal treatment and diagnostic efforts.
- Early recognition and aggressive therapy are critical for managing such infections in vulnerable neonates.

## Abstract

Extremely preterm neonates are at heightened risk for invasive fungal infections. We report a fatal case of Aspergillus flavus infection in a 25-week infant, outlining the clinical course, antifungal treatment, and challenges in management. This case highlights the need for early recognition, rapid biopsy and aggressive therapy in vulnerable neonates.

## Linked entities

- **Species:** Aspergillus flavus (taxon 5059)

## Full-text entities

- **Diseases:** Aspergillus flavus infection (MESH:D001228), fungal infections (MESH:D009181)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12769400/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12769400/full.md

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Source: https://tomesphere.com/paper/PMC12769400