This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: Downregulation of FBP1 Promotes Tumor Metastasis and Indicates Poor Prognosis in Gastric Cancer via Regulating Epithelial-Mesenchymal Transition

Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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TopicsFibroblast Growth Factor Research · Protein Tyrosine Phosphatases · Kruppel-like factors research
Following the publication of this article [1] concerns were raised with results presented in Figs 4 and 5. Specifically,
The authors did not respond to the journal’s request for comments.
In light of the above concerns which call into question the reliability and integrity of the published results, the PLOS One Editors retract this article.
All authors either did not respond directly or could not be reached.
In addition to the above concerns, the PLOS One Editors are also aware of similarities between:
PLOS notes that [2] and [4] were published at a later date by researchers who do not appear to share affiliations with the authors of [1].
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Li J, Wang Y, Li Q-G, Xue J-J, Wang Z, Yuan X, et al. RETRACTED: Downregulation of FBP 1 Promotes Tumor Metastasis and Indicates Poor Prognosis in Gastric Cancer via Regulating Epithelial-Mesenchymal Transition. P Lo S One. 2016;11(12):e 0167857. doi: 10.1371/journal.pone.0167857 27978536 PMC 5158319 · doi ↗ · pubmed ↗
- 2Wang X-H, Jiang Z-H, Yang H-M, Zhang Y, Xu L-H. Hypoxia-induced FOXO 4/LDHA axis modulates gastric cancer cell glycolysis and progression. Clin Transl Med. 2021;11(1):e 279. doi: 10.1002/ctm 2.279 33463054 PMC 7809603 · doi ↗ · pubmed ↗
- 3Cao L, Chen C, Zhu H, Gu X, Deng D, Tian X, et al. MMP 16 is a marker of poor prognosis in gastric cancer promoting proliferation and invasion. Oncotarget. 2016;7(32):51865–74. doi: 10.18632/oncotarget.10177 27340864 PMC 5239520 · doi ↗ · pubmed ↗
- 4Mao A, Zhou X, Liu Y, Ding J, Miao A, Pan G. KLF 8 is associated with poor prognosis and regulates glycolysis by targeting GLUT 4 in gastric cancer. J Cell Mol Med. 2019;23(8):5087–97. doi: 10.1111/jcmm.14378 31124603 PMC 6653475 · doi ↗ · pubmed ↗
- 5Cao F, Sun H, Yang Z, Bai Y, Hu X, Hou Y, et al. Multiple approaches revealed M Gc 80-3 as a somatic hybrid with He La cells rather than a gastric cancer cell line. Int J Cancer. 2024;154(1):155–68. doi: 10.1002/ijc.34677 37543987 · doi ↗ · pubmed ↗
- 6Yang M, He J, Xia S, Wang Y, Xiong J, Liao C, et al. Investigation of the mixed origins of the MGC-803 cell line reveals that it is a hybrid cell line derived from He La. Hum Cell. 2024;37(2):560–6. doi: 10.1007/s 13577-023-01011-4 38079103 · doi ↗ · pubmed ↗
