# BioLogical: a universal analysis framework for biosystem logical dynamics

## TL;DR

BioLogical is an R package that helps analyze the logical dynamics of biosystems, especially gene regulatory systems, through a user-friendly framework.

## Contribution

The novel contribution is the development of a universal, flexible framework for analyzing biosystem logical dynamics with multi-valued and hierarchical capabilities.

## Key findings

- BioLogical can decipher logical paradigms and compute biosystem indicators effectively.
- The package supports simulation of system evolution and logical satisfiability evaluation.
- It provides a standard workflow adaptable to diverse biosystem analysis needs.

## Abstract

Complex biosystems exhibit ordered, functional, self-organized features, yet a universal framework for exploring their logical paradigms and dynamic behaviors remains lacking. Here we present BioLogical, a user-friendly R package designed to analyze logical properties of gene regulatory systems. Through a standard workflow and multiple cases, we demonstrate its versatile capabilities in deciphering logical paradigms, computing static and dynamic biosystem indicators, simulating system evolution, and evaluating logical satisfiability. All concepts and algorithms are extended to multi-valued scenarios, and hierarchical interfaces are provided to meet diverse requirements. The open-source software is available at https://github.com/YuxiangYao/BioLogical.