# Preventing and Managing Vascular Complications in Adolescents With Type 1 Diabetes

**Authors:** Beatrice Prampolini, Cansu Ceren Eryılmaz, M. Loredana Marcovecchio

PMC · DOI: 10.1155/jdr/2449658 · Journal of Diabetes Research · 2025-12-29

## TL;DR

This paper reviews how to prevent and manage vascular complications in adolescents with Type 1 diabetes through early detection and treatment strategies.

## Contribution

The paper emphasizes early screening and comprehensive treatment strategies for vascular complications in youth with Type 1 diabetes.

## Key findings

- Adolescents with Type 1 diabetes often have risk factors for vascular complications.
- Early subclinical vascular complications can be detected in youth with diabetes.
- Intensive diabetes management and screening can delay or halt complications.

## Abstract

The morbidity and mortality associated with Type 1 diabetes are primarily linked to vascular complications. While overt clinical manifestations of microvascular complications and cardiovascular disease predominantly occur during adulthood, a noteworthy proportion of adolescents with Type 1 diabetes have one or more risk factors for the development of vascular complications. In addition, early subclinical stages of vascular complications can be detected already in youth with diabetes. Intensive diabetes management and targeted screening strategies can effectively delay or halt the progression of these complications. Preventative strategies should focus on three main principles: achieving optimal glycemic targets, preventing and targeting cardiometabolic risk factors, and implementing early screening programs. For managing complications, a comprehensive approach is essential, combining insulin therapy to optimize glycemic targets, motivational lifestyle interventions, and timely pharmacological treatments. This review summarizes the epidemiology and risk factors for vascular complications in youth with Type 1 diabetes and emphasizes the importance of early detection and prevention, and effective treatment strategies.

## Linked entities

- **Diseases:** Type 1 diabetes (MONDO:0005147), cardiovascular disease (MONDO:0004995)

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}
- **Diseases:** diabetes (MESH:D003920), Type 1 Diabetes (MESH:D003922), Vascular Complications (MESH:D003925), complications (MESH:D008107), cardiovascular disease (MESH:D002318)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12767235/full.md

## References

87 references — full list in the complete paper: https://tomesphere.com/paper/PMC12767235/full.md

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Source: https://tomesphere.com/paper/PMC12767235