Methylation Landscapes of Cartilage in Hip Osteoarthritis
Ruiyang Jiang, Maochun Wang, Guihua Tan, Jie Lv, Xiaoyu Jin, Yuan Liu, Rui Wu, Dongquan Shi
TL;DR
This study compares DNA methylation patterns in cartilage from hip osteoarthritis and femoral neck fracture to identify genes and pathways involved in the disease.
Contribution
The study reveals genome-wide methylation differences in preserved and damaged cartilage in hip osteoarthritis.
Findings
Preserved and damaged cartilage showed distinct methylation profiles compared to femoral neck fracture cartilage.
Differential methylation was enriched in extracellular matrix and KEGG pathways like PI3K-AKT and AMPK.
Six genes showed methylation changes correlated with expression levels in different cartilage types.
Abstract
To elucidate different methylation landscapes between cartilage of femoral neck fracture and preserved and damaged cartilages in hip osteoarthritis (OA). Genome‐wide DNA methylation data were acquired from two data sets in GEO database (GSE63106 and GSE63695), which were based on Illumina HumanMethylation450 BeadChip arrays. A total of 63 hip samples were selected for further analysis, including 19 cartilages obtained from patients with femoral neck fracture, 14 preserved cartilages, and 30 damaged cartilages obtained from patients with OA. We identified the differential methylated positions (DMPs) and genes between different cartilage groups. There were 116,750 DMPs and 51,200 DMPs identified in preserved and damaged cartilages compared to cartilage in femoral neck fracture, respectively, while there were no signals found between preserved and damaged cartilages. Gene ontology…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsOsteoarthritis Treatment and Mechanisms · Total Knee Arthroplasty Outcomes · Bone and Joint Diseases