# Sustainable electrochemical synthesis of aliphatic nitro-NNO-azoxy compounds employing ammonium dinitramide and their in vitro evaluation as potential nitric oxide donors and fungicides

## TL;DR

A sustainable electrochemical method was developed to synthesize aliphatic nitro-NNO-azoxy compounds using ammonium dinitramide, which also showed potential as nitric oxide donors and fungicides.

## Contribution

A green electrochemical synthesis method using ammonium dinitramide as both oxidant and reagent is introduced.

## Key findings

- The method allows for atom- and step-economical synthesis of aliphatic nitro-NNO-azoxy compounds.
- The synthesized compounds exhibit significant nitric oxide donor activity and fungicidal properties.
- The process is scalable and practical, using constant current electrolysis in an undivided cell.

## Abstract

An atom- and step-economical electrochemical method for the synthesis of aliphatic nitro-NNO-azoxy compounds from the corresponding nitroso compounds was developed employing ammonium dinitramide, a prospective green oxidant for aerospace propulsion applications, as both electrolyte and source of a =NNO2 group. The developed method is green, practical, and scalable due to constant current electrolysis in an undivided cell at high current densities. Synthesized products demonstrated pronounced NO-donor activity and fungicidal activity against phytopathogenic fungi.