First discovery of triterpenoids and sterols from Cotinus coggygria var. cinereus Engl. with anti-inflammatory and antibacterial activities
Yue-Tong Zhu, Ze-Rui Li, Ren-Hao Chen, Jin-Hao Li, Wei Wang, Yu-Qi Gao, Chun-Huan Li, Jin-Ming Gao
TL;DR
Researchers discovered new triterpenoids and sterols from a plant with anti-inflammatory and antibacterial properties.
Contribution
The study reports the first isolation of triterpenoids and sterols from Cotinus coggygria var. cinereus, including four new compounds.
Findings
Compound 15 showed anti-inflammatory activity with an IC50 of 6.81 ± 0.15 μM.
Coggygrenoid C (3) inhibited methicillin-resistant Staphylococcus aureus with an MIC of 8 μg/mL.
Combining compound 3 with ampicillin enhanced antibacterial effects in a Galleria mellonella model.
Abstract
This study led to the isolation of 17 triterpenoids, including two lanostane-type (1 and 2), two dammarane-type (3 and 7), ten tirucallane-type (4 and 8−16), and three oleanane-type (17−19) triterpenoids, as well as nine sterols (5, 6, and 20−26) from Cotinus coggygria var. cinereus Engl, which were first discovered from the genus Cotinus. Among them, coggygrenoids A−D (1−4), coggygrerol A (5), and coggygrerol B (6) are undescribed compounds. Additionally, seven flavonoids (27−33) were also isolated from this plant. Compound 15 displayed inhibitory activities in LPS-induced RAW 264.7 cells with an IC50 value 6.81 ± 0.15 μM. Molecular docking demonstrated that 15 exhibited favorable affinity for NLRP3 and iNOS. In vitro and in vivo antibacterial evaluations indicated that coggygrnoid C (3) exhibited significant inhibitory activity against methicillin-resistant Staphylococcus aureus ATCC…
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Taxonomy
TopicsTannin, Tannase and Anticancer Activities · Pomegranate: compositions and health benefits · Ginkgo biloba and Cashew Applications