Aseptic Meningitis and Papillary Edema: Uncommon Presentation of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

TL;DR

This paper discusses a rare case where a brain antibody disease showed up as meningitis, highlighting unusual symptoms and high spinal fluid pressure.

Contribution

The paper presents a rare case of MOGAD presenting with aseptic meningitis and high CSF pressure, expanding the known clinical spectrum of the disease.

Findings

MOGAD can present with prolonged aseptic meningitis without typical neurological symptoms.

High cerebrospinal fluid opening pressures are a notable feature in these rare cases.

Review of literature shows similar cases of MOGAD initially presenting with meningitis symptoms.

Abstract

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune disease characterized by central nervous system demyelination. We report a case of prolonged aseptic meningitis in which anti-MOG antibodies were subsequently detected. In addition, we review previously reported cases of MOGAD that initially presented with symptoms of meningitis. MOGAD with meningitis without neurological symptoms or parenchymal brain lesions was rare and characterized by high cerebrospinal fluid (CSF) opening pressures.

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