# Unrecognised Second-Trimester Pregnancy With Fetal Demise Presenting as Acute Abdomen and a Negative Pregnancy Test

**Authors:** Marwa E Desouky

PMC · DOI: 10.7759/cureus.98517 · 2025-12-05

## TL;DR

A woman with a missed pregnancy and fetal demise showed negative pregnancy test results, emphasizing the need for imaging in such cases.

## Contribution

This case highlights the possibility of false-negative pregnancy tests in advanced fetal demise and the importance of early imaging.

## Key findings

- A negative urine pregnancy test can occur in cases of fetal demise due to declining hCG levels.
- Imaging is crucial for diagnosing unrecognized pregnancies with fetal demise.
- Clinical suspicion is essential when symptoms suggest pregnancy despite negative tests.

## Abstract

A woman in her early 20s presented with abdominal pain and a heavy period, unaware that she was 18 weeks pregnant. Despite a negative urine pregnancy test, imaging revealed intrauterine fetal demise. This rare case highlights the importance of maintaining clinical suspicion and performing early imaging, as pregnancy tests may yield false-negative results in cases of miscarriage and fetal demise. Human chorionic gonadotropin (hCG) is produced by the placenta, but when a pregnancy fails to develop normally, such as in miscarriage, hCG levels may be lower than expected or decline, leading to negative test results despite advanced gestation.

## Linked entities

- **Proteins:** CGA (glycoprotein hormones, alpha polypeptide)

## Full-text entities

- **Genes:** CGB5 (chorionic gonadotropin subunit beta 5) [NCBI Gene 93659] {aka CGB, HCG}
- **Diseases:** miscarriage (MESH:D000022), Abdomen (MESH:D000006), abdominal pain (MESH:D015746)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12765394/full.md

---
Source: https://tomesphere.com/paper/PMC12765394