# Physical and Emotional Interventions in Modulating Neuroplasticity: A Narrative Review of Recent Evidence

**Authors:** Britty Babu, Fathima Mohideen Bawa, Gauri Parvathy, Anya R Gupta, Gurnoor S Gill, Alfredo A Paredes, Adja Seitaj, Daniela Herbert, Manish Gupta

PMC · DOI: 10.7759/cureus.98446 · 2025-12-04

## TL;DR

This review explores how physical activity and emotional interventions may influence brain plasticity, but highlights the need for more consistent research.

## Contribution

The paper provides a narrative review of recent evidence on physical and emotional interventions modulating neuroplasticity.

## Key findings

- Exercise is associated with increased BDNF and synaptic plasticity.
- Emotional interventions like mindfulness show variable effects on neural adaptation.
- Cognitive training aids functional recovery in stroke and TBI, but results are inconsistent.

## Abstract

Neuroplasticity, the brain’s capacity to adapt structurally and functionally in response to experiences, is a key factor in recovery from neurological conditions. Growing interest has focused on physical and emotional interventions as potential modulators of neuroplastic processes. A narrative review was conducted using a structured PubMed search of articles published between January 2018 and March 2023. Studies were included if they examined physical activity, emotional well-being, or cognitive training, with outcomes relevant to neuroplasticity. Publications outside these parameters, non-English studies, and case reports were excluded. Twenty-seven articles met the inclusion criteria.

The literature described a range of possible influences. Exercise was frequently linked with markers such as brain-derived neurotrophic factor (BDNF) and synaptic plasticity. Emotional interventions, including stress reduction and mindfulness, were reported to have variable effects on neural adaptation. Cognitive training was discussed in relation to functional recovery in conditions such as stroke and traumatic brain injury (TBI). Findings across studies were heterogeneous, and conclusions were limited by differences in study designs and outcome measures.

Current evidence suggests that both physical and emotional interventions may influence neuroplasticity, though results are not uniform. The diversity of methodologies and measured outcomes indicates that more rigorous and standardized research is needed. While the reviewed literature points to potential benefits of physical and emotional interventions in modulating neuroplasticity, evidence remains preliminary. Further high-quality longitudinal studies are required to clarify their role in neurological rehabilitation and clinical care.

## Linked entities

- **Proteins:** BDNF (brain derived neurotrophic factor)
- **Diseases:** stroke (MONDO:0005098), traumatic brain injury (MONDO:0858950)

## Full-text entities

- **Genes:** BDNF (brain derived neurotrophic factor) [NCBI Gene 627] {aka ANON2, BULN2}
- **Diseases:** TBI (MESH:D000070642), stroke (MESH:D020521)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12765202/full.md

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Source: https://tomesphere.com/paper/PMC12765202