Successful Pregnancy Following Ovarian Platelet-Rich Plasma (PRP) Treatment, the DuoStim Protocol, and Preimplantation Genetic Testing for Aneuploidy in a Patient With Premature Ovarian Insufficiency: A Case Report

TL;DR

A woman with premature ovarian insufficiency successfully gave birth after a combination of PRP treatment, ovarian stimulation, and genetic embryo testing.

Contribution

This case report demonstrates a novel multidisciplinary approach combining PRP, DuoStim, and PGT-A to achieve pregnancy in a patient with POI.

Findings

PRP treatment helped restore ovarian function in a patient with POI.

Combining DuoStim with PGT-A led to a successful pregnancy and healthy child birth.

The approach suggests potential for overcoming reproductive barriers in POI patients.

Abstract

Premature ovarian insufficiency (POI) severely limits reproductive options. We report a successful live birth in a patient with POI following a combined approach of intraovarian platelet-rich plasma (PRP) treatment, double ovarian stimulation (DuoStim protocol), and preimplantation genetic testing for aneuploidy (PGT-A). PRP treatment was performed to restore ovarian function, after which DuoStim was used to maximize oocyte yield. An embryo obtained underwent PGT-A, and transfer of a euploid blastocyst resulted in an uncomplicated pregnancy and the birth of a healthy child. This case highlights the potential of personalized and multidisciplinary strategies to overcome the traditional barriers in POI by integrating regenerative medicine (PRP), advanced ovarian stimulation (DuoStim), and genetic embryo selection (PGT-A). While this innovative approach appears promising for women with diminished ovarian reserve, further studies are needed to confirm its efficacy and safety.

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