The impact of gut-liver-derived mediators on the organ crosstalk with brain, heart, and kidney: A systematic review
Shruti Bhargava, Zhuangting Rao, Raymond Vanholder, Frank Tacke, Heidi Noels, Vera Jankowski, Juliane Hermann, Joachim Jankowski
TL;DR
This review explores how gut and liver-derived molecules affect the brain, heart, and kidneys, highlighting gaps in understanding and the need for holistic approaches to disease.
Contribution
The study systematically identifies and categorizes 28 gut-liver-derived mediators and their effects on multiple organs.
Findings
28 gut-liver-derived mediators were identified and grouped into five molecular categories.
The mediators' mechanisms of action on the brain, heart, and kidneys were reviewed.
The findings highlight gaps in understanding gut-liver pathways and their impact on comorbidities.
Abstract
The current understanding of interactions and crosstalk among essential organs remains incomplete, mainly due to the limitations of studies on the systemic mechanisms at play. The gut and the liver are essential for the functioning of the entire body, and their derived mediators circulate through blood or lymph, impacting other organs like the brain, heart, and kidneys. This publication reviews gut-liver-derived mediators, which were tested and validated in vivo in humans and rodents, together with the current knowledge of their systemic effects on key vital organs. Original articles published up to February 2025, based on clinical trials or in vivo experimental models, were retrieved from PubMed and Web of Science. During this systematic analysis, 28 gut-liver-derived mediators were identified from 52 publications and classified into five distinct groups based on their molecular…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsLiver physiology and pathology · Barrier Structure and Function Studies · Gastrointestinal motility and disorders