# Social Connection and Brain Age in Females and Males

## TL;DR

This study finds that social connection factors like living arrangements and marital status affect brain age differently in males and females among older adults.

## Contribution

The study reveals novel sex-specific associations between structural social connection and brain age acceleration in older adults.

## Key findings

- Living with someone or being married was linked to lower brain age acceleration in males.
- Females who lived with someone or were married showed higher brain age acceleration.
- These associations were not observed for employment/volunteering or social networks.

## Abstract

Poor social connection is associated with negative health outcomes in aging – including dementia. Structural aspects of social connection include marital status, living arrangements, employment/volunteering, and social networks. Sex-related differences in the structure of social connection have been observed in aging but how they relate to brainageR – or other machine learning estimates of the biological age of a brain – is currently unknown. This study of 171 Ashkenazi Jewish older adults without dementia from the LonGenity study (M Age = 72.59 years; 59% female) aimed to determine if sex modified associations between structural social connection measures (marital status, living arrangements, employment/volunteering, social networks) and brainageR acceleration (AgeAccel). Brain AgeAccel was defined as the residual from regressing machine learning-predicted brainageR estimates on chronological age. Separate linear regression models adjusted for potential confounders were applied to each social connection measure, and the interaction term between sex and social connection was the effect of interest in each model. Living arrangements (alone/with someone) and marital status (married/not married) – but not employment/volunteering (yes/no) or social networks (social network index) – were differentially associated with brain AgeAccel in males and females. Males who lived with someone or were married had lower brain AgeAccel (better) than males who lived alone or were unmarried. Females who lived with someone or were married had higher brain AgeAccel (worse) than females who lived alone or were unmarried. These novel sex-specific associations are interesting but need the be confirmed in larger and more diverse samples of older adults.