BIOMARKERS OF AGING - A CONSORTIUM STORY
Mahdi Moqri
TL;DR
This paper discusses efforts by a consortium to develop and validate biomarkers that can measure biological aging and help evaluate anti-aging interventions.
Contribution
The paper presents collaborative work to address the lack of consensus on validating aging biomarkers for clinical use.
Findings
The Biomarkers of Aging Consortium has worked over three years to address validation challenges.
The paper highlights the need for standardized validation before clinical translation of aging biomarkers.
Abstract
The search for biomarkers that quantify biological aging has intensified in recent years. Such biomarkers could predict aging-related outcomes and could serve as surrogate endpoints for the evaluation of interventions promoting healthy aging and longevity. However, no consensus exists on how biomarkers of aging should be validated before their translation to the clinic. I will present the work on the Biomarkers of Aging Consortium over the past three years to address this unmet need.
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Taxonomy
TopicsGenetics, Aging, and Longevity in Model Organisms · GDF15 and Related Biomarkers · Frailty in Older Adults