# Acculturation and Age Acceleration: Differences Between Hispanic and Non-Hispanic Immigrants

## TL;DR

This study finds that acculturation affects biological aging differently for Hispanic and non-Hispanic immigrants in the U.S.

## Contribution

The paper is the first to examine how acculturation relates to epigenetic age acceleration in Hispanic and non-Hispanic immigrants.

## Key findings

- Hispanic immigrants who migrated at a young age or after 1965 showed biological age deceleration.
- Non-Hispanic immigrants who migrated later in life or more recently showed biological age acceleration.
- Acculturation appears to have divergent effects on aging between Hispanic and non-Hispanic immigrant groups.

## Abstract

Acculturation by immigrants to the United States is tied to dissipating immigrant health advantages, but its relationship to epigenetic age acceleration (AA) has not been studied. Further, acculturation may affect Hispanic and non-Hispanic immigrants differently. We estimated the effects of acculturation on epigenetic AA by Hispanic ethnicity using 2nd & 3rd generation epigenetic age clocks from the Health and Retirement Study (N = 4014). AA scores were defined as standardized residuals from models regressing each clock on chronological age. Acculturation measures included immigration age (0-15 years,16-40, 41-90 vs. non-immigrant); time since immigration (0-39 years, 40+ vs. non-immigrant); immigration year (1923-1964, 1965-2009 vs. non-immigrant); and English spoken at home (yes, no vs. non-immigrant). We predicted mean AA scores per acculturation measure level from confounder-adjusted regression models separately for Hispanics and non-Hispanics; we computed contrasts & 95% confidence intervals (Contrast [95% CI]) between predicted means for each acculturation measure level vs. non-immigrants. Hispanic immigrants showed net age deceleration if they migrated between ages 0-15 (Levine/PhenoAge= -0.28 [-0.56, 0], migrated after 1965 (Levine/PhenoAge = -0.18 [-0.36, -0.01]); GrimAge = -0.17 [-0.32, -0.01]), and regardless of whether they spoke English at home (Levine/PhenoAge = -0.3 [-0.57, -0.04]; GrimAge = -0.16 [-0.31, 0]). Non-Hispanic immigrants showed net age acceleration if they migrated between ages 41-90 (Levine/PhenoAge=0.49 [0.14, 0.84]; DunedinPoAm38 = 0.33 [0.02, 0.65]); immigrated 0-39 years ago (Levine/PhenoAge = 0.26 [0.04, 0.49]); and if they migrated after 1965 (Levine/PhenoAge = 0.2 [0.02, 0.38]). Acculturation may lead to aging advantages for Hispanic immigrants, but disadvantage for non-Hispanics immigrants.

---
Source: https://tomesphere.com/paper/PMC12762442