# Associations between objective sleep measures and proteomic aging: The ARIC Study

## TL;DR

Poor sleep is linked to faster biological aging based on protein levels, suggesting better sleep could help prevent age-related diseases.

## Contribution

This study identifies specific sleep patterns associated with proteomic age acceleration using objective sleep and proteomic data.

## Key findings

- Sleep-disordered breathing and less REM sleep are linked to higher proteomic age acceleration.
- Longer sleep duration and disrupted sleep patterns are associated with increased proteomic aging over time.
- Lower oxygen levels during REM sleep correlate with faster proteomic aging.

## Abstract

Increasing evidence links poor sleep to accelerated biological aging; however, associations between sleep and proteomic age acceleration (PAC) remain understudied. We examined these associations among 1,554 participants (mean age 60.5±5.5 years, 99.0% White) in the Atherosclerosis Risk in Communities study (ARIC; waves 3 [1993-1995], 5 [2011-2013]) and the Sleep Heart Health Study (SHHS; waves 1 [1996]) who had polysomnography and proteomic data. Predictors were sleep-disordered breathing (SDB) and hypoxia, and sleep architecture, fragmentation, and duration (SHHS w1). Outcomes were proteomic age, derived from plasma (ARIC w3/w5; SomaScan v.4) using four published clocks (Wang, Sathyan, Tanaka, Lehallier). Linear regression assessed cross-sectional associations between sleep and PAC (ARIC w3); linear mixed models assessed associations between sleep and PAC longitudinal changes over time (ARIC w3 and w5). All models adjusted for age, race, education, study site, smoking, alcohol use, BMI, and sleep medication. Cross-sectionally, SDB (Wang: B = 0.59 [0.04, 1.14]; Sathyan: 0.91 [0.06, 1.76]), less REM sleep (Tanaka: -0.04 [-0.07, -0.01]; Lehallier: -0.03 [-0.06, -0.00] ), and lower sleep efficiency (Tanaka: -0.02 [-0.05, -0.00]) were associated with higher PAC. Longitudinally, lower REM oxyhemoglobin saturation (Sathyan: −0.27 [−0.45, −0.08]; Tanaka: −0.17 [−0.31, −0.03]), less slow-wave sleep (Tanaka: −0.03 [−0.05, −0.01]), higher arousal index (Tanaka: 0.03 [0.00, 0.05]), lower sleep efficiency (Wang: −0.05 [−0.09, −0.00]), and sleep > 8 h (Wang: 0.83 [0.05, 1.60]; Sathyan: 1.33 [0.35, 2.31]) were associated with increasing PAC (all p < 0.05). Findings suggest poor sleep accelerates proteomic aging, emphasizing sleep health as a target for aging-related disease prevention.

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Source: https://tomesphere.com/paper/PMC12761724